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Using Tahoe-100M to find new immunomodulators
How the world’s largest single-cell transcriptomic dataset unlocked drugs that enhance tumor visibility through MHC-I upregulation.
Jun 5 • 
Tahoe Therapeutics
5

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Using Tahoe-100M to find new immunomodulators

April 2025

The Tahoe Blog
Today we’re launching The Tahoe Blog. In the same open-source spirit that led us to release Tahoe-100M—our gigascale, perturbative single-cell…
Apr 30 • 
Nima Alidoust

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The Tahoe Blog
Saquinavir Unmasked: An Adrenoceptor Agonist In Disguise
Tahoe-100M revealed that Saquinavir unexpectedly mimics mechanisms such as adrenoceptor agonism, explaining clinical off-target effects discovered after…
Apr 30 • 
Tahoe Therapeutics
9

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Saquinavir Unmasked: An Adrenoceptor Agonist In Disguise
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