Reversal as a Drug Discovery Strategy: The Search for Perturbations That Restore Normal Cell States

Using Tahoe 100M to prioritize drugs by their ability to reverse the cancer cell state

Feb 11 • Tahoe Therapeutics

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October 2025

Target Deconvolution Through Data Integration: Unifying Drug and Genetic Perturbations

Tahoe-100M links drug and genetic perturbation maps to rapidly deconvolute targets, expose hidden pathways, and guide design of drugs that phenocopy…

Oct 3, 2025 • Tahoe Therapeutics

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July 2025

Accelerating Single-Cell Deep Learning with scDataset and Tahoe-100M

We at Tahoe love developer tools that make it easier to build on Tahoe-100M. This is a guest post highlighting the work of D. D'Ascenzo and S. Cultrera…

Jul 16, 2025

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June 2025

Using Tahoe-100M to find new immunomodulators

How the world’s largest single-cell transcriptomic dataset unlocked drugs that enhance tumor visibility through MHC-I upregulation.

Jun 5, 2025 • Tahoe Therapeutics

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April 2025

The Tahoe Blog

Today we’re launching The Tahoe Blog. In the same open-source spirit that led us to release Tahoe-100M—our gigascale, perturbative single-cell…

Apr 30, 2025 • Nima Alidoust

Saquinavir Unmasked: An Adrenoceptor Agonist In Disguise

Tahoe-100M revealed that Saquinavir unexpectedly mimics mechanisms such as adrenoceptor agonism, explaining clinical off-target effects discovered after…

Apr 30, 2025 • Tahoe Therapeutics

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