Archive - The Tahoe Blog

Using Tahoe-100M to find new immunomodulators

How the world’s largest single-cell transcriptomic dataset unlocked drugs that enhance tumor visibility through MHC-I upregulation.

Jun 5 •

Tahoe Therapeutics

5

April 2025

The Tahoe Blog

Today we’re launching The Tahoe Blog. In the same open-source spirit that led us to release Tahoe-100M—our gigascale, perturbative single-cell…

Apr 30 •

Nima Alidoust

Saquinavir Unmasked: An Adrenoceptor Agonist In Disguise

Tahoe-100M revealed that Saquinavir unexpectedly mimics mechanisms such as adrenoceptor agonism, explaining clinical off-target effects discovered after…

Apr 30 •

Tahoe Therapeutics

9

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